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Fig. 8. 3-D reconstruction of representative wild-type and
Pn-1-deficient adult cerebella. (A-F) Half-cerebella of
two representative wild-type (Pn-1+/+; A,C,E) and
Pn-1-deficient mutant (B,D,F) mice are shown as 3-D reconstructions
from different angles. (A,B) The cerebella shown as mid-sections. Notice that
the overall size of the mutant cerebellum (B) is increased. In particular,
lobes V and IX appear extended in the direction of the yellow arrows. (C,D)
The cerebella shown from a posterior angle. In the mutant mouse, lobe IX
(yellow arrow), again appears enlarged in its mid-part (red double arrows).
(E,F) View from the mid-anterior side. The central part of the mutant
cerebellum appears clearly enlarged (red double arrows) and lobe IX (yellow
arrows) protrudes more than in its wild-type counterpart.
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