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Figure 5


Fig. 5. Impaired I12b enhancer activity in the telencephalon following mutagenesis of protein-binding sites. Transverse sections through the telencephalon of E11.5 transgenic mouse embryos (such as those shown in Fig. 4). The plane of section is schematized. Two series of transverse sections corresponding to the rostral (A,C,E,G,I,K,M) and middle (B,D,F,H,J,L,N) regions of the telencephalon are shown. Expression obtained with the wild-type I12b enhancer (A,B) and following mutagenesis of (C,D) the first DLX/MSX/NKX2.5-binding site, (E,F) MEIS1 site, (G,H) FP3 site, (I,J) second DLX/MSX/NKX2.5 site, (K,L) MASH1 site, and (M,N) FP6 homeodomain site. Cx, cortex; IZ, intermediate zone; LGE, lateral ganglionic eminence; MGE, medial ganglionic eminence; AEP, anterior entopeduncular area; POA, preoptic area; VT, ventral telencephalon; SCB, suprachiasmatic band (a diencephalic structure). Scale bar: 500 µm.





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