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Figure 1


Fig. 1. The Snai1 and Snai2 genes are essential for palate development. (A,B) Scanning electron micrographs showing cleft secondary palate at E17.5 in Snai1+/- Snai2-/- mutant embryos. (C,D) Coronal sections at E15 showing the fused secondary palate in control embryos (C), and the adjacent, but unfused palatal shelves in Snai1+/- Snai2-/- mutant embryos (D). (E-H) Expression of the Snai1 gene in the developing palate of E13.5 and 14.5 embryos. Note the expression in the palatal shelf mesenchyme at each stage and the strong expression adjacent to the MES at E14.5 (inset). (I,J) Snai2 expression, detected by ß-galactosidase activity of the Snai2lacZ allele, showing widespread expression in the palatal shelf mesenchyme and nasal/oral epithelia. Note the increase in ß-galactosidase activity in mice with deletion of a single Snai1 allele (J). ns, nasal septum; ps, palatal shelf; t, tongue; tb, tooth bud. Scale bar: 100 µm in C,D,I,J; 200 µm in E-H.





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