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Fig. 4. Cleft palate and craniofacial abnormalities in
Snai1/2-dko mice. (A,B) Whole-mount
in situ hybridization for Snai1 of E9.5 control and
Snai1-cko embryos showing effective deletion of Snai1 by
Wnt1-Cre in the neural crest. Note the absence of Snai1
expression in the first branchial arch (arrow in B) in the mutant embryo
versus control. (C,D) Histology of the cleft palate in
Snai1/2-dko embryos, showing the vertically oriented palatal
shelves in mutant embryos. (E,F) Skulls of
Snai1/2-dko mice are smaller, dome-shaped, and have a
shortened mandible (arrow). (G,H) Ventral view of the mandible
of control (G) and mutant (H) neonates. Note the overall shorter length,
missing rostral Meckel's cartilage and midline fusion (arrow) in the mutant.
(I,J) An enlarged frontal foramen (asterisk) is apparent in the
Snai1/2-dko neonate. Scale bar: 200 µm in A,B; 100 µm
in C,D; 2 mm in E,F; 1 mm in G-J.
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