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Fig. 2. The keratin cytoskeleton is collapsed in primary cultures of
Mrj-/- trophoblast cells. (A) Keratinfilament
(red) organization in trophoblast giant cells derived from wild-type and
Mrj-/- chorionectoplacental cone explants. (B)
Quantification of the types of keratin-filament organization observed in
trophoblast giant cells derived from wild-type and Mrj-/-
chorionectoplacental cone explants. (C) Ultrastructure of a keratin
aggregate (surrounded by broken line) in a Mrj-/-
trophoblast giant cell at E8.25. (D) Mrj expression (red) in
trophoblast giant cells of a wild-type conceptus at E8.25. Right,
higher-magnification of boxed region in the left panel. (E) Nuclear
(left), cytoplasmic (center), and both nuclear and cytoplasmic (right) Mrj
expression in wild-type trophoblast giant cells in vitro. Arrowheads indicate
trophoblast giant cells with undetectable Mrj expression. Broken line
indicates the periphery of a trophoblast giant cell. (A,D,E) DNA is blue. ch,
chorion; em, embryo; pan-CK, pan-cytokeratin; TGC, trophoblast giant cells.
Scale bars: 10 µm in A,E; 0.5 µm in C; 20 µm (left) and 10 µm
(right) in D.
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