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Figure 6


Fig. 6. Chorioallantoic attachment is rescued in Mrj-/-;K18+/- and Mrj-/-;K18-/- conceptuses. (A) An unattached allantois (arrow) of an E9.5 Mrj-/- embryo appears as a bud at the posterior end of the embryo. Broken line outlines the chorion (Ch). (B-D) Chorioallantoic attachment of K18-/- (B,C) and K18-/-;K19-/- (D) conceptuses at E9.5. (C) Higher-magnification of the boxed region in B. (E,F) Rescued chorioallantoic attachment in Mrj-/-;K18+/- (E) and Mrj-/-;K18-/- (F) conceptuses at E9.5. (G-I) Branching morphogenesis in Mrj-/-;K18+/- (H) and Mrj-/-;K18-/- (I) placentas with rescued chorioallantoic attachment at E9.5 compared to a Mrj+/-;K18+/+ littermate placenta (G). White arrowheads, fetal blood space/branchpoint; asterisks, maternal blood space; Ch, chorion; Al, allantois; black arrowhead, allantois. Scale bars: 1 mm in A,B; 0.5 mm in C,D; 0.5 mm in E,F; 20 µm in G-I.





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