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Figure 3


Fig. 3. Predicted WLE3 secondary structure is conserved. (A) Alignment of Drosophila wg 3'UTR sequences with D. melanogaster WLE3 (nucleotides 525-568). Sequences are listed, top to bottom, in order of divergence from D. melanogaster (based on full-length 3'UTR pair-wise comparisons). Invariant residues are shaded black, and bases at variable positions similar to the consensus are shaded grey. Compensatory mutations that preserve base-pairing are shaded green and base-pair disrupting mutations red (*sequences obtained from Drosophila genome projects). (B) Predicted secondary structures for D. melanogaster, D. yakuba, D. prosaltans, D. hydei and Z. tuberculatus WLE3 sequences. Invariant residues are in black text and consensus residues in grey. Non-consensus residues that preserve or disrupt conserved base pairs are green or red, respectively. Non-consensus residues in the loop and central `variable' region are blue. (C) Consensus secondary structure predicted by ALIFOLD. Invariant residues are black, consensus residues grey and positions with conserved base-pairing green.





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