spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. Weak Uba1 alleles suppress apoptosis. (A) GMR-hid eye disc labeled with cleaved Caspase-3 (Cas3*) antibodies. Yellow arrows indicate two zones of dying cells in GMR-hid. (B,B') Suppression of Cas3*-positive cell death in GMR-hid discs. The yellow arrow indicates the position of the first zone of Cas3*-positive cell death in GMR-hid. Uba1D6 clones suppress Cas3*-positive cell death (white arrows). However, this suppression is not uniform and occurs in a region-specific manner. Clones in an area of the disc marked by the red arrow are still apoptotic. Genotype: GMR-hid ey-FLP; FRT42D Uba1D6/FRT42D P[ubi-GFP]; (C-C'') Uba1D6 clones suppress most normal developmental cell death in 28 hours APF pupal discs. Genotype as in B. (D-D'') Uba1H33 clones contain additional IOCs in 42 hours APF pupal discs. Genotype: ey-FLP; FRT42D Uba1H33/FRT42D P[ubi-GFP]. (E-E'') Diap1 protein levels are increased in Uba1H33 mutant clones (arrows). Genotype as in D. (F-F'') Dronc protein levels are decreased in Uba1D6 mutant clones (arrows). Genotype as in B.





Right arrow Return to article