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Fig. 2. Thapsigargin treatment disrupts organ laterality and molecular
asymmetry. (A-C) Dorsal view, 30 hpf, showing nkx2.5
expression in the heart tube, denoting a left jog in wt (A), and no jog (B) or
right jog (C) in thapsigargin-treated embryos. (D-F) Dorsal view, 48
hpf, white arrows indicate foxA3 gut expression in wt (D) and
symmetrical (E) or reverse loop (F) in thapsigargin-treated embryos.
(G-I) Dorsal view, 19-23 somites, arrows indicate left-sided
spaw expression in (G) wt, and (H) bilateral or (I) right-sided
expression in thapsigargin-treated. Dorsal view, 19-23 somites, arrows
indicate LPM, dashed arrows indicate brain lefty1 expression on the
left side in (J) wt, and (K) bilateral in thapsigargin-treated,
arrowheads denote lefty1 expression in the midline. Lateral view of
ntl expression in (L) wt and (M) thapsigargin-treated,
and shh expression in (N) wt and (O)
thapsigargin-treated embryos. (P) Summary of asymmetrical marker
expression.
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