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Fig. 5. Adherens junction integrity is not compromised in MALS^TKO embryos. (A,B) Coronal sections of E18.5 embryos immunostained for ZO1 to identify adherens junctions reveal normal staining in MALS^TKO. (C-F) Antibodies against β-catenin (C,D) and pan-cadherin (E,F), both of which localize to the apical surface at the adherens junctions, reveal no change in MALS^TKO mice relative to controls. (G-L) Coronal sections of E17.5 embryos stained with antibodies against nestin (G,H), to identify neural progenitors, and GFAP (K,L), to reveal glial cells, reveal no difference between MALS^TKO mice and controls. (I,J) However, antibodies against the neuronal marker TuJ1 reveal a broader TuJ1 staining pattern in the cortex of MALS^TKO embryos, suggesting that MALS^TKO progenitors quit cycling prematurely and differentiate into neurons. Scale bars: 10 µm.

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