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Figure 6


Fig. 6. MALSTKO embryos display significant differences in labeling index and quit fraction during early neurogenesis. (A-H) Coronal sections of E11.5 (A,B), E12.5 (D,E) and E13.5 (G,H) MALSTKO mutants and matching littermate control brains injected with BrdU 2 hours (A,B,G,H) or 24 hours (D,E) before sacrifice. Sections were immunostained with antibodies to BrdU (A,B,D,E,G,H) and Ki67 (D,E). (C) At E11.5, MALSTKO progenitors have a lower labeling index (total number of BrdU+ cells/total number of cells) than do controls. (F) A larger number of MALSTKO mutant progenitors at E12.5 have quit the cell cycle relative to control littermates (BrdU+ Ki67-/total number of BrdU+ cells). (I) MALSTKO mutant progenitor cells recover normal cell-cycle dynamics just a day later at E13.5, at which time no differences in the labeling index are apparent. Scale bar: 10 µm.





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