spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. Model of DMP development in mutant backgrounds. Shh has multiple roles in AV septation, depicted by schematic sagittal sections at E11.5. (A) Shh produced by foregut endoderm (blue) signals to adjacent DM (green) allowing for mesenchymal movement into the atria and subsequent formation of the DMP. DM-derived endocardium (dark green) and splanchnic mesoderm (red) are also added to the atria at this time. (B) Global loss of Shh results in a failure of DMP development as well as abnormal AV cushion shape, probably owing to OFT and right ventricle shortening. (C) Loss of receptiveness for Hh signaling in the myocardium, endocardium and mesenchyme derived from the endocardium (TnT-Cre; Tie2-Cre; Smoflox/-) does not recapitulate the Shh-null AVSD phenotype. (D) While Shh is maintained in Mef2C-AHF-Cre; Smoflox/- mutants, lack of receptiveness in DM leads to failure of these cells to develop into the DMP.





Right arrow Return to article