QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online April 25, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Patterning needs a little sweetener

N-linked glycosylation is a protein modification needed for protein folding in the endoplasmic reticulum (ER). If unfolded proteins accumulate in the ER, then the `unfolded protein response' (UPR) is triggered, increasing folding rates and reducing translation rates. On p. 1745, Mattias Mannervik and colleagues describe the first embryonic patterning defects known to be caused by an inappropriate UPR. In their screen for maternal factors involved in embryonic patterning, they discovered a mutant - wollknäuel (wol) - that has reduced Dpp signalling, posterior segmentation defects due to a lack of the transcription factor Caudal, and defects in germband elongation and retraction. wol encodes ALG5, a UDP-glucose:dolichyl-phosphate glucosyltransferase involved in N-linked glycosylation, and its mutation causes the accumulation of unglycosylated proteins and triggers the UPR. One component of the UPR is the phosphorylation of the translation initiation factor eIF2, which attenuates protein translation. These findings suggest that some mRNAs, such as caudal, are particularly sensitive to eIF2 phosphorylation, resulting in the wol patterning defects.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Wollknäuel is required for embryo patterning and encodes the Drosophila ALG5 UDP-glucose:dolichyl-phosphate glucosyltransferase

Achim Haecker, Mattias Bergman, Christine Neupert, Bernard Moussian, Stefan Luschnig, Markus Aebi, and Mattias Mannervik
Development 2008 135: 1745-1749. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?