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Fig. 2. mop acts on internalized EGFR. All panels show third instar Drosophila eye discs. Photoreceptors are stained with anti-Elav (A,C,E,G,I,K,M,O; magenta in B,D,F,H,J,L,N,P). (A,B) mop^T482 mutant clones are positively marked by GFP expression (green in B, outlined in A). (C,D) Clones expressing EGFRtop are positively marked by GFP expression (green in D, outlined in C). (E,F) mop^T612 mutant clones expressing EGFRtop are positively marked by GFP expression (green in F, outlined in E). (G,H) mop^T612 mutant clones expressing Ras^v12 are positively marked by GFP expression (green in H, outlined in G). (I-P) Large clones generated in a Minute background are marked by the absence of GFP (green in J,L,N,P, outlined in I,K,M,O). (I,J) mop^T612; (K,L) mop^T612 aos⁷; (M,N) mop^T612 Cbl^F165; (O,P) mop^T612 sty⁵. Although EGFRtop induces photoreceptor differentiation in a wild-type background, it does not rescue mop mutant clones; removing aos also fails to rescue. Photoreceptor differentiation can be restored to mop mutant clones by expressing Ras^v12 or removing Cbl or sty.

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