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Fig. 6. The Gurken internalization was blocked in Cbl mutant follicle cells. Anterior of the egg chamber is towards the left and dorsal side faces upwards. Wild-type cells were marked by anti-Myc antibody (red). Mosaic egg chamber containing Cbl mutant clones and an HRP-grk transgene were obtained from females of the genotype e22cFLP/grk^HFHRP-grk; Cbl^F165FRT^80B/MFRT^80B. (A,B) Gurken expression (green) pattern was not markedly altered in egg chambers containing Cbl mutant follicle cell clones. (C,D,F-H) Punctate HRP-Grk signal was significantly reduced in the posterior (C,D), dorsal (F,G) and ventral (H) follicle cells, in which Cbl was homozygous mutant (areas indicated by brackets). When a large Cbl mutant clone was present in the dorsal region, the punctate HRP-Grk signal could be detected in follicle cells situated more posteriorly (F, arrows indicate punctate HRP signals; G, open stars indicate the 10th follicle cells) than in wild-type egg chambers (E). The 1st main body follicle cell was the one overlying the border between nurse cells and the oocyte (indicated by a star). Scale bars: 40 µm in A,B; 20 µm in C,D; 10 µm in E-H.

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