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Figure 3


Fig. 3. Cell proliferation is similarly reduced in PTHrP-/- and PTHrP-/-;Ptch1c/-;Col2a1-Cre mutant cartilage. (A) Comparison of BrdU-labeled chondrocytes in the cartilage of different mutants and in the wild-type control. Boxed regions are shown at higher magnification in the lower panel. The highly proliferating columnar chondrocytes (bracket) were reduced in the PTHrP-/-;Ptch1c/-;Col2a1-Cre mutant. (B) Percentage of BrdU-labeled chondrocytes in the columnar regions (circled in A), calculated from three independent samples to get the mean±s.d. Student's t-test, P<0.05.





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