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Figure 4


Fig. 4. Distinct pharmacological properties of EPPs recorded from wild-type and {gamma}-/- muscles. (A) Sample EPP traces recorded from wild-type or {gamma}-/- muscles in normal Ringer's, or in Ringer's with {alpha}A-conotoxin OIVB (10 µM). (B) Quantification of normalized EPP amplitudes. EPPs in wild-type muscles, but not {gamma}-/- muscles, were sensitive to {alpha}A-conotoxin OIVB. (C) Sample EPP traces recorded from wild-type or {gamma}-/- muscles in normal Ringer's, or in Ringer's with waglerin 1 (1 µM). (D) Quantification of normalized EPP amplitudes. Bath application of waglerin 1 (1 µM) in Ringer's completely blocked the EPPs in the {gamma}-/- muscles, but was much less effective in the wild-type muscles. *P<0.05, ***P<0.001 (Student's t-test).





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