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Figure 7


Fig. 7. More severe RGC loss in Isl1 and Brn3b compound null mice. (A-H) Immunostaining of adult whole-mount retinas with anti-BRN3A (A-D) and SMI32 (E-H). A more severe loss of BRN3A+ RGCs (red) and SMI32+ axon bundles (green) is observed in Isl1/Brn3b-null retina. (I-L) Ventral views of brains reveal optic nerves (arrows). Compared with the controls (I), optic nerve size is reduced in Isl1 nulls (J) and Brn3b nulls (K). The optic nerves are barely detectable in Isl1/Brn3b-null mice (L). (M-O) X-Gal staining of Brn3b-lacZ-expressing RGCs in E13.5 retina sections shows that the genesis and migration of RGCs are undisturbed in Brn3b-null (N) and Isl1/Brn3b-null (O) retinas. L, lens; GCL, ganglion cell layer. Scale bars: 50 µm in D and H; 800 µm in L and 100 µm in O.





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