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Figure 3


Fig. 3. Ngn2-expressing progenitors generate dentate granule neurons at the onset of dentate gyrus formation. (A-C) Sections through the hippocampus of wild-type (A,B) and Ngn2KIGFP/+ (C) embryos at E16.5. (A1-C1) High magnification of the areas outlined in A-C. (A1'-C1'') Single-channel images of the pictures in A1-C1. Ngn2-expressing cells in primary and secondary matrices incorporate BrdU after a 30-minute pulse (A,A1), and co-express Ki67 (B,B1). (C,C1) GFP+ cells in Ngn2KIGFP/+ dentate gyrus co-express Prox1 at low or high level. Almost all dentate granule neurons (Prox1high) are GFP+ and therefore originate from Ngn2-expressing progenitors. Arrows indicate double-labelled cells. The different progenitor populations of the developing DG (1ry, primary matrix; 2ry, secondary matrix; 3ry, tertiary matrix) are outlined. Scale bars: 50 µm.





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