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Fig. 4. Abnormal development of the dentate gyrus in Ngn2 mutant
mice. (A,A') Haematoxylin/Eosin staining of
hippocampal sections of E18.5 Ngn2 mutant (A') and wild-type
(A) embryos show the lack of a morphologically distinct dentate gyrus
(asterisk) in mutant brains at this stage. (B,B') Sections
through the hippocampus of 1-month-old (P28) Ngn2 mutant (B')
and wild-type mice (B) show the absence of the lower blade of the DG
(asterisk) in mutant brains. (C,C') High magnification of
the upper blade of the wild-type (C) and Ngn2 mutant (C')
dentate gyrus. Note the disorganized appearance of the mutant DG. Scale bars:
100 µm.
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