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Fig. 6. Reduction in the number of granule neurons in the dentate gyrus of Ngn2 mutant mice. (A-B') Sections through the hippocampus of E16.5 Ngn2^KIGFP/+ (A,B) or Ngn2^KIGFP/GFP (A',B'). (A,A') Sections showing Prox1^high- and Prox1^low-expressing cells. Both Prox1^low progenitors and Prox1^high granule neurons are reduced in Ngn2^KIGFP/GFP. The areas outlined in A,A' indicate the regions shown in B,B'. (B,B') Brains immunolabelled for GFP and Prox1. Insets B1,B'1 show Prox1^high granule neurons expressing GFP at a higher magnification. Arrows indicate double-labelled cells. (C,D) Histograms representing (C) the number of cells expressing Prox1^low (light colour) or Prox1^high (dark colour) and (D) the number of Casp3-positive cells at E15.5 and E16.5 in Ngn2^KIGFP/+ (blue bars) and Ngn2^KIGFP/GFP (red bars) dentate gyrus. Fewer (Prox1^low progenitors and Prox1^high granule neurons are present in Ngn2^KIGFP/GFP embryos. ^*P0.05, ^**P0.01.

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