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Fig. 7. Neuronal differentiation defects in Ngn2 mutant dentate gyrus. (A,A',B,B',C,C') Sections through the hippocampus of P1 Ngn2^KIGFP/+ (A,B,C) or Ngn2^KIGFP/GFP (A',B',C') brains immunolabelled for GFP and HuC/D (A,A'), Prox1 (B,B') or Neurod1 (C,C'). The insets show a high magnification of the secondary matrix. (A'',B'',C''). Histograms representing (A'') the percentage of GFP⁺ cells expressing HuC/D, (B'') the percentage of GFP⁺ cells expressing Prox1^low (light colour) or Prox1^high (dark colour), and (C'') the percentage of GFP⁺ cells expressing Neurod1 in Ngn2^KIGFP/+ (blue bars) and Ngn2^KIGFP/GFP (red bars) dentate gyri. Fewer post-mitotic HuC/D, Prox1^high-expressing granule neurons are present in the Ngn2^KIGFP/GFP DG, while Ngn2 loss of function does not affect Neurod1 expression. ^*P $≤$ 0.05, ^**P $≤$ 0.01. Scale bars: 50 µm.

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