|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 7. Detachment of myofilaments at the MTJ. Electron micrographs of
tibialis (A-E), diaphragm (F-J) and soleus (K,L)
muscles collected from 1-month-old (A-C,H,I) and 6-month-old (D-G,J-L)
wild-type (WT) and Tln1 mutant (MT) mice. In wild-type mice,
myofilaments connected to junctional electron-dense plaques are visible
(arrowheads in A,D,F). In 1-month-old Tln1HSA-CREko mice, most MTJs
were intact (B), but detachment of myofibers from MTJs was occasionally
observed (C). In 6-month-old mutant animals, detachment of the myofibers was
observed very frequently (E). Necrotic material was present where myofibers
detached (asterisks in C,E,G). The thickness of the junctional plaque was
reduced, and gaps were present where myofilaments failed to attach (arrows in
G). Degeneration (I) and accumulation (K,L) of mitochondria were observed.
Necrotic areas were observed in mutant fibers (J,K, asterisk) next to abnormal
myofilaments (K, arrows). Scale bars: 3 µm in A-E,H,I; 1 µm in F,G; 10
µm in J-L.
|
