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Fig. 1. C3G expression and histology of the developing cerebral cortex of the C3G^gt/gt mutant. (A-F) In situ hybridisation using a C3G-specific cRNA probe (A,B,D,E) or sense control probe (C,F) on adjacent sections of wild-type mouse cerebral cortex at E12.5 (A-C) and E15.5 (D-F). Bright-field (A,D) and corresponding dark-field (B,E) images. Silver grains representing C3G mRNA distribution appear white in the dark-field image (B,E,C,F). (G-N) Haematoxylin and Eosin stained paraffin sections of wild-type (G,I,K,M) and C3G^gt/gt mutant (H,J,L,N) developing cerebral cortex at E12.5 (G,H), E13.5 (I,J) and E14.5 (K-N). Images were taken using differential interference contrast optics, which reveal unstained or weakly stained structures. Arrows in G indicate basement membrane and arrowheads in H the lack thereof. Stippled line in I indicates the demarcation between the neuroepithelium and the pericerebral tissue; arrowheads in J indicate neuroepithelial cells invading the pericerebral space. Dashed line in M indicates ventricular-to-pial orientation of cortical plate cells. CNE, cortical neuroepithelium; CP, cortical plate; IZ, intermediate zone; LV, lateral ventricle; MZ, marginal zone; SP, subplate; SVZ, subventricular zone; VZ, ventricular zone. Scale bar: 197 µm in A-C; 94 µm in D-F; 13 µm in G,H; 32 µm in I,J; 38 µm in K,L; 18 µm in M,N.

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