spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 1


Fig. 1. Abnormal skin development and Wnt/β-catenin pathway activation in stabilized β-catenin mutant embryos. (A-H) Control littermate and KRT14-Cre Ctnnb1(Ex3)fl/+ (Act β-catenin) embryos at the stages indicated. Arrows indicate keratinized plaques in mutant embryos. (I,J) Higher magnification views of dorsal skin from G and H, respectively. Pigment (arrows) accumulates in mutant skin. (K,L) Immunohistochemistry for β-catenin at E15.5 showing elevated β-catenin levels in control placodes (K), and cytoplasmic and nuclear β-catenin throughout mutant ectoderm (L, arrows). (M-P) X-gal-stained control BATgal (M,O) and KRT14-Cre Ctnnb1(Ex3)fl/+ BATgal (Act β-catenin BATgal) (N,P) littermates at E13.5 (M,N) and E16.5 (O,P), showing increased BATgal expression and its irregular pattern in the mutant. Scale bar in L applies to K and L.





Right arrow Return to article