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First published online May 23, 2008

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Angiogenesis and β1 integrin stick together

Integrins - heterodimeric cell-surface receptors that bind to laminin, collagen and other ligands in the extracellular matrix (ECM) - propagate many intracellular signals during development. For example, integrin-ECM interactions regulate the formation of new blood vessels (angiogenesis). But which integrin-ligand pairs are required in endothelial cells (ECs) to mediate this process? Carlson and co-workers now report that β1 integrin is needed for EC adhesion, migration and survival during angiogenesis (see p. 2193). Lineage-specific deletion of Itgb1 (which encodes β1 integrin) in ECs in mouse embryos causes embryonic lethal vascular defects, they report, including the formation of a discontinuous endothelium in blood vessels. Furthermore, isolated Itgb1-null ECs behave in a disorganised manner, fail to adhere to or migrate on laminin or collagen substrata and have reduced survival. These findings highlight the essential role that β1 integrin plays during angiogenesis and suggest that targeted therapies that block the function of β1 integrins in ECs could control the growth and survival of cancers by preventing neovascularisation.

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Related articles in Development:

Cell-autonomous requirement for β1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice

Timothy R. Carlson, Huiqing Hu, Rickmer Braren, Yung Hae Kim, and Rong A. Wang
Development 2008 135: 2193-2202. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?