spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 4


Fig. 4. HSD-1 is involved in {Delta}4-dafachronic acid synthesis. (A) HSD-1 may function in the proposed biosynthetic pathway of {Delta}4- and {Delta}7-dafachronic acids [modified, with permission from Rottiers et al. (Rottiers et al., 2006)]. Predicted intermediates for biosynthesis of {Delta}7- and {Delta}4-dafachronic acids from cholesterol are indicated in the upper and lower branches of the pathway, respectively. The marked positions on the cholesterol structure (1-7) represent the standard numbering of the carbon atoms. 5-cholesten-3-one, in parentheses, is the presumed product, from cholesterol, after the first of the two-step 3β-HSD reactions. Shaded triangles and ovals indicate the sequential changes that HSD-1 is hypothesized to direct: triangles indicate 3β-dehydrogenase activity, ovals indicate isomerase activity. (B) The structures of ergosterol and β-sitosterol, the major fungal and plant sterols, respectively.





Right arrow Return to article