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Fig. 5. ns156 alters MLS-2, an Nkx/HMX-related homeodomain protein.
(A) mls-2(ns156) rescue studies. Strains were scored
as in Fig. 4. VL/R, ventral
left/right CEPsh glia. n, number of animals. C39E6, mls-2
cosmid. One representative line is shown for each construct. The
mls-2 genomic locus construct contains 8.3 kb surrounding and
including the gene. (B) C. elegans mls-2 gene structure.
Boxes, exons; 
-shaped lines, introns; the homeodomain is in blue.
(C) Alignment of homeodomains and HMX motifs of MLS-2 and related
proteins. Pink, identical in all; blue, identical in all but one or two
proteins; gray, present in five proteins. (D-J) (D) Diagram of ventral
nuclei positions in a 270-minute embryo [adapted with permission from Sulston
et al. (Sulston et al.,
1983)]. (E,H) Enlarged regions of D, (F,I) DIC and (G,J)
fluorescence images of a ventral right (E-G) and left (H-J) CEPsh glial cell
precursor (red arrowhead) in a 270-minute embryo expressing
mls-2::GFP. (K-N) Same as D-G but showing dorsal left and
right CEPsh glia precursors.
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