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Fig. 1. Effect of QT6-Shh cell graft in BA1 presumptive territory on lower-jaw
morphogenesis. (A) Graft of QT6-Shh cells (outlined), under the
ectoderm, lateral to the posterior mesencephalon, in a 5 ss chick embryo, on
its right side. (B) Cross-section at the level of the graft at 10 ss.
In situ hybridization for Shh shows the QT6-Shh cells in contact with
lateral ectoderm (Ect) and foregut endoderm (End). (C) Lateral right
view of the head at E11 showing the normal lower beak (1) and two
supernumerary hemi-lower-beaks (2,3) with mirror-image polarities (1/2 and
2/3). (D) Skeleton preparation of the embryo shown in C. The right
lower jaw shows a large proximal Meckel's cartilage (arrow) prolonged by three
distinct branches of cartilage (1-3). The quadrate and articular (arrowhead)
are not perturbed. (E) Higher magnification of D showing that each
branch of Meckel's cartilage (1-3) is associated with a dentary bone (white
arrows) oriented in mirror image. (F) Higher magnification of
structures 1 and 2 viewed through the left side (control side) allows the
comparison of the normal left Meckel's cartilage (nMc) and the larger right
experimental one (eMc), and shows mirror-image duplication of splenial (black
arrows) and dentary bones (white arrows). Scale bar: 50 µm in B.
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