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Figure 8


Fig. 8. A model for oral epithelium induction by the foregut endoderm or by the graft of QT6-Shh cells in the chick BA1 territory. (A,B) A 6 ss chick embryo cross-sectioned at the normal oropharyngeal level (A), and at the level of grafted QT6-Shh cells (purple spot) (B). Gene inductions elicited by normal (A') and ectopic (B') sources of Shh (purple) are indicated. (C) Expression of Fgf8 (green), Bmp4 (red) and Shh (purple) in BA1 ectoderm of QT6-Shh grafted (on the left) and control (on the right) sides at E4. Curved arrows indicate growth orientation of the further normal (1) and induced (2 and 3) Meckel's branches. (C') Virtual section of the experimental BA1 (broken line) indicates three distinct lower jaw organizing centers (1-3) presenting Fgf8/Shh/Bmp4 alternations in the normal (1) and induced (2,3) jaw anlagen. I, first branchial arch; I', induced part of I; II, second branchial arch; Ect, ectoderm; End, endoderm; Ao, aortic arch. A'' and B'', normal oral epithelium and induced `oral-like epithelium'.





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