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Figure 3


Fig. 3. Blood vessel structure of Lkb1lox/-, Tie1-Cre conceptuses at E11.5. (A,B) Whole-mount VE-cadherin staining of wild-type (A) and Lkb1lox/-, Tie1-Cre (B) yolk sacs. (C,D) Whole-mount PECAM1 staining of wild-type (C) and Lkb1lox/-, Tie1-Cre (D) yolk sacs. Insets show higher magnification of single vessels. (E,F) Hematoxylin and Eosin-stained sagittal sections from wild-type (E) and Lkb1lox/-, Tie1-Cre (F) embryos. Arrows indicate the aortas; asterisks, the livers. Arrowhead in F indicates congested blood in the Lkb1lox/-, Tie1-Cre aorta.





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