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First published online June 6, 2008

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Wnt signal transduction via Src kinases in developing CNS

During nervous system development, axons are guided by many attractive and repulsive cues. For example, members of the RYK/Derailed family of inactive receptor tyrosine kinases guide axons in the Drosophila ventral nerve cord and in the mammalian brain by acting as Wnt receptors. On p. 2277, Wouda et al. reveal how these kinase-inactive RYKs might transduce Wnt signals by reporting that WNT5-mediated signalling through Derailed in the Drosophila embryonic CNS involves the non-receptor Src family tyrosine kinases SRC64B and SRC42A. Src64B/Src42A double mutants, they show, have defects in the formation of the nerve fibre tracts that connect the two sides of the brain (commissures) similar to those seen in Wnt5 and derailed mutants. Derailed and SRC64B, they report, form a complex, the formation and/or stability of which requires SRC64B activity. Furthermore, the mammalian orthologues of these proteins also form complexes together. Thus, Src family kinases might play novel roles in Wnt5/Derailed signalling during CNS development in flies and in mammals.

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Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system

Rene R. Wouda, Monique R. K. S. Bansraj, Anja W. M. de Jong, Jasprina N. Noordermeer, and Lee G. Fradkin
Development 2008 135: 2277-2287. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?