QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online June 6, 2008

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

A tail of axial progenitors

The vertebrate tail bud is thought to contain multipotent progenitor cell populations that generate the embryo's axial structures (the neural tube, notochord and paraxial mesoderm). Now, by grafting tissue from a new transgenic chick line in which all embryonic cells express GFP into unlabelled embryos, McGrew and colleagues identify three progenitor cell populations in the avian tail bud (see p. 2289). Cells from the embryonic chordoneural hinge, they report, contribute descendants to all of these axial structures, whereas cells from the dorsoposterior tail bud yield mesodermal tissue only. Both these populations are likely to be `long-term axial progenitors' because they are retained in the tail bud after serial transplantation. By contrast, a ventral tail bud cell population, which also generates paraxial mesoderm, is not retained after serial transplantation. Finally, by showing that transplantation of tail bud progenitor cells into earlier embryos resets their Hox expression (which determines the anteroposterior identity of axial cells), the researchers challenge the idea that Hox identity is fixed during gastrulation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity

Michael J. McGrew, Adrian Sherman, Simon G. Lillico, Fiona M. Ellard, Pippa A. Radcliffe, Hazel J. Gilhooley, Kyriacos A. Mitrophanous, Noemí Cambray, Valerie Wilson, and Helen Sang
Development 2008 135: 2289-2299. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?