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Fig. 2. Aberrant projections of sensory afferents. (A-L) Spinal cord sections immunolabelled for TrkA at E12.5 (A-D), E13.5 (E-H) and E14.5 (I-L) in wild-type (WT; A,B,E,F,J), TAG-1-null (C,G,I,K) and L1 null (D,H,L) mice. Boxes in A and E indicate typical regions shown in B-D and F-H, respectively, at higher power; boxes in I are magnified in K; broken lines indicate the dorsal midline. Arrowheads highlight aberrant projections. Scale bars: 100 µm. (M) Mean number of aberrant projections calculated at E12.5, E13.5 and E14.5 in wild-type (n=8, 4 and 6 embryos, respectively), L1-null (n=6, 3 and 5) and TAG-1-null mice (n=7, 5 and 6). Horizontal bars indicate significant differences (unpaired t-test, ^***P<0.001, ^**P<0.01, ^*P<0.05). Error bars throughout are s.e.m. (N) Proportion of axons projecting into medial (green) or lateral (blue) regions. Red lines indicate significant differences (Chi-squared test; significance as above). (O) Proportion of axons projecting from medial (orange) or lateral (cyan) regions of the DF. Red lines indicate significant differences (Chi-squared test; significance as above).

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