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Fig. 4. Gene set enrichment during mouse mammary development. (A)
Lactation (days 1, 3 and 7) and involution (days 1-4) samples were used in
GSEA. An example of the enrichment analysis is shown with the random walk for
the androgen-regulated gene set as well as the heatmap of the individual genes
that compose the gene set. (B) ASSESS, a version of GSEA, was applied
to the same data with the normalized enrichment scores being reported on a
sample-by-sample basis for each gene set. Results from selected gene sets are
shown. (C) In addition, the pubertal dataset was examined, with the two
phenotypic classes based on the differential sample clustering from
Fig. 2B, and the normalized
enrichment scores are shown for a number of gene sets.