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Fig. 5. Pathway activation probabilities. (A) The probability of
pathway activation was examined in the developmental and pubertal datasets.
STAT3 and p63, well-established mammary markers, were initially used to
validate this method in the mammary development dataset. (B) In
addition, a variety of genetic pathways were analyzed for their probability of
activation in the developmental dataset, including MYC, β-catenin, RAS,
SRC, a knockout signature for Rb, E2F1, E2F2, E2F3 and E2F4. (C) Other
phenotypic and genetic pathways were also examined for the probability of
their activation including TNF, RHOA, TGFβ, basal/luminal status,
endotoxin infection and an immune signature. (D) In addition, the
pubertal data were subjected to the same analysis and relevant results are
shown.
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