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Figure 5


Fig. 5. Genetic reduction of chordin, noggin and Nodal causes molecular laterality defects that are rescued by decreasing Bmp4 dosage. (A-K) Ventral views of 5s mouse embryos hybridized with Nodal probe. The node region is boxed. Arrowheads indicate Nodal expression in LPM. (A) Wild type, (B) Nodal+/-, (C) Chrd-/-, (D,E) Chrd-/-;Nodal+/-, (F) Chrd-/-;Nog+/-, (G,H) Chrd-/-;Nog+/-;Nodal+/-, (I) Chrd-/-;Nog+/-;Bmp4+/- and (J,K) Chrd-/-;Nog+/-;Nodal+/-;Bmp4+/-. At the bottom of each panel is a summary of the Nodal expression in the left LPM and the level of perinodal Nodal expression [normal (++) or weak (+)]. Orange indicates the presence of Nodal expression in left LPM, gray its absence.





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