spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.


Figure 7


Fig. 7. LvNumb requires a functional Notch signal. High levels of Notch signaling override the requirement for LvNumb during NSM specification and LvNumb is necessary for the expression of the earliest known Notch target. (A) (a) Pluteus larvae injected with control morpholino have normal numbers of pigment cells. (b) Injection of either ptb domain mRNA (2 pg/pl) or (f) LvNACT mRNA (2 pg/pl) increases pigment cell specification. (c) Embryos injected with either LvNNEG (3 pg/pl) or (g) LvNumb morpholino display a lack of pigment cells. (d) Injection of ptb domain mRNA in embryos expressing LvNNEG does not rescue pigment cell specification. (h) Expression of LvNACT (2 pg/pl) rescues pigment cell specification in 86% of the embryos injected with the LvNumb morpholino (1.8 mM). (B) (a) A mesenchyme blastula stage embryo injected with control morpholino shows gcm expression in the NSM. (b,c) Embryos injected with LvNumb2 morpholino show reduced (b) or no expression of gcm (c).





Right arrow Return to article