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Figure 3


Fig. 3. c-Myc deficiency causes apoptotic loss of primitive erythroblasts. (A) H&E staining of control and Sox2Cre;c-mycflox/flox YS at E10.5. Control YS vessels contain numerous hematopoietic cells (arrows), whereas mutant vessels are mostly devoid of hematopoietic cells (arrows), although individual cells are sometimes observed (arrowheads). (B) FACS analysis of the primitive embryonic system at E11.0. CD71 and Ter119 are used to define primitive proerythroblasts (PPE; CD71-Ter119+) and primitive erythroblasts (PE; CD71+Ter119+). (C) Quantitative analysis of total PPE and PE number in control and c-Myc-deficient embryos at E11.0 (**P≤0.001). (D) Quantitative analysis of TUNEL-positive CD71+ cells in E9.5 and E10.5 embryos (**P≤0.001).





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