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Figure 3


Fig. 3. Separating the role of blood flow from Nrp1 function. (A) Pecam1 staining of yolk sacs from cultured heterozygote and mutant embryos in both flow and no-flow conditions, as indicated. In heterozygote embryos with flow, a large remodeled artery (Art) is visible. Heterozygote embryos without flow fail to remodel capillaries into large vessels. Insets show collagen IV staining on sections from E9.5 yolk sacs that also highlight the large vessel diameters in Nrp1-/- yolk sacs compared with wild type. (B-D) Nrp1-/- vessels, with or without flow, show decreased branching (B), increased vessel segment length (C) and increased avascular spaces (D). **P<0.01; ***P<0.005; Student's two-tailed t-test. Scale bar: 100 µm.





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