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Fig. 7. Abnormalities in the lumbar, sacral and tail regions of OE2 mice.
(A,B) Numbers indicate the most posterior vertebrae bearing ribs
and the first sacral vertebrae. Green dots in B show the outline of the tail.
Mis-alignments of lumbar (C) and caudal (D) vertebrae.
(E) Wild-type tail. (F-H) Arrows show split centres of
ossification (F) and multiple tail axes. (I) Club-tail of Bouin's fixed
10.5 day OE2 peak-expresser sired embryo showing irregularly sized and spaced
somites (small arrows) and, in transverse section (J), failure of
neural tube closure and increased mass of mesodermal component relative to
wild type (K). Large arrow in I shows the level of section J. L, lumbar
vertebra; np, neural plate; nt, neural tube; s, somitic mesoderm; n,
notochord; g, hindgut. Scale bar: 0.2 mm in J,K.
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