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Fig. 2. Formation of Cajal-Retzius cells and choroid plexus epithelial cells in
the dorsal telencephalic midline. pEF-EGFP was introduced into the dorsal
telencephalic midline at E9.5 by in utero microelectroporation, and the fate
of EGFP+ cells was examined at the indicated time points. For the
orientation of the planes, see Fig.
1A,A'. (A-F) At E10.5, all EGFP+ cells
resided in the Msx1+ region (A-C). At E11.5, many
EGFP+ cells migrated tangentially into the cortical neuroepitheium
(D,E), and some of them had already reached the marginal zone of the piriform
cortex (D,F). (G-Q) At E12.5, all cells that migrated laterally seemed
to have reached the piriform cortex (G, arrow). Only two regions, the choroid
plexus epithelium (the origin, asterisk) and the piriform cortex (the
destination, arrow) were labeled with EGFP (G). The cells that remained at the
origin expressed transthyretin (Ttr) (H,I,O,P) but not
reelin (Q). The cells that migrated into the piriform cortex expressed
Lhx5 (J,K, adjacent sections), Tuj1 (L,L') and reelin
(M,M', arrowheads) but not calretinin (N,N'). di, diencephalon;
tel, telencephalon. Scale bars: 150 µm in A,D; 500 µm in G; 50 µm in
L-Q.
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