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Fig. 3. Expression of Hes1 and Hes5 in the dorsal
telencephalic midline. (A) Scheme of a dorsal view of E12.5
forebrain. Coronal sections are made along the broken line. (B) Schemes
of the coronal sections of the dorsomedial telencephalon at E10.5-E12.5.
(C-F) At E10.5, the dorsal telencephalic midline expressed
Bmp4 and Lmx1a (C,D). Hes1 was likewise expressed
in this region as well as in the neighboring diencephalic and telencephalic
neuroepithelium (E). Hes5 was expressed at a lower level in this
region than in the telencephalic neuroepithelium (F). (G-N) At E11.5,
the Bmp4 and Lmx1a expression domain was elongated (G,H).
Msx1 and Ttr were expressed in differentiating choroid
plexus epithelium (I,J), whereas Wnt2b was expressed in the
prospective cortical hem (K). Hes1 expression was gradually
downregulated in Ttr+ cells (L). Although Hes5
expression was upregulated in the telencephalon and the diencephalon, it was
also downregulated in Ttr+ cells (M). Wnt2b+
and Msx1+ domains were clearly separated at this stage (N).
(O-T) At E12.5, the choroid plexus epithelial cells became thin and
cuboidal (R, Ttr+), whereas the cortical hem was still
pseudostratified. Bmp4 and Lmx1a were expressed in both
regions (O,P). Msx1 expression occurred mainly in the choroid plexus
epithelium (Q), whereas Wnt2b expression occurred in the cortical hem
(R). Hes1 and Hes5 expression was almost completely
repressed in the choroid plexus epithelium (S,T). Scale bars: 100 µm in
C-F; 200 µm in G-T.
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