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Figure 9


Fig. 9. Summary of developmental defects of the dorsal telencephalic midline region of Hes1;Hes3;Hes5 cKO mice. (A) In Hes1;Hes3;Hes5 cKO mice, the choroid plexus epithelium (cpe) is lacking, and Cajal-Retzius (CR) cell formation in the piriform cortex (pir) is enhanced. (B) Ngn2 promotes Cajal-Retzius cell formation, whereas Hes genes regulate specification of the choroid plexus epithelium by antagonizing Ngn2. In Hes1;Hes3;Hes5 cKO mice, Ngn2 expression is upregulated and Cajal-Retzius cell formation is enhanced, whereas choroid plexus epithelial cells are lacking. ctx, neocortex; hem, cortical hem; emt, eminentia thalami.





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