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Figure 3


Fig. 3. HLEB is conserved from mammals to cartilaginous fish. (A) VISTA plot (Frazer et al., 2004) comparing the 654 bp mouse HLEB sequence against sequences from human, opossum, platypus, chicken, lizard, frog, teleost fish (stickleback) and cartilaginous fish. Percentage sequence identity [y-axis, ranging from 40% to 100% (lower to upper thick line in each panel)] is shown in a sliding window across the region (x-axis, bp). Pink shading indicates regions of 20 bp or more that are ≥65% identical. (B,C) Whole-mount lacZ staining of E12.5 transgenic mouse embryos. (B) Hsp68LacZ transgene pDBM5 with four copies of mouse HLEB. (C) Hsp68LacZ transgene pDBM20 with four tandem copies of stickleback HLEB.





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