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Figure 7


Fig. 7. Model of the paracrine signaling network influenced by deletion of Klf5. mRNAs that were significantly altered in lungs from Klf5{Delta}/{Delta} mice were subjected to literature mining to identify potential functional associations and regulatory relationships using Pathway Studio 5.0 (Ariadne Genomics). KLF5 influenced the expression of genes previously associated with various signaling pathways, including those regulated by PDGF, FGF and TGFβ. mRNAs increased in Klf5{Delta}/{Delta} mice are framed in red, those decreased are framed in green. Each line indicates a regulatory relationship between gene nodes based upon literature references. Regulatory relationships are denoted by line colors and patterns: purple lines represent binding; blue lines represent regulation of expression; the gray lines represent `regulation'; and arrows with a plus indicate positive regulation.





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