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Fig. 5. Loss of β-catenin mediated by the Sf1/Crehigh
transgene results in a decreased number of adrenocortical cells at least
partly due to decreased proliferation. BrdU incorporation into wild-type
and Sf1/Crehigh-mediated KO mice was determined at the indicated
stages as described in the Materials and methods. Mice with
Sf1/Crehigh-mediated β-catenin KO appeared to have decreased
BrdU staining in the region of the adrenal primordium. The graphs show
quantitation of Sf1-positive cells (top) and Sf1-positive cells that were also
positive for BrdU (bottom) in E12.5 and E13.5 embryos. The number of
Sf1-positive cells was decreased significantly at both E12.5
(*P<0.01 versus wild type) and E13.5
(**P<0.01 versus wild type), whereas the number of
doubly labeled cells was only decreased significantly at E13.5
(**P<0.01 versus wild type). Scale bars: 50 µm.
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