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Fig. 11. picasso mutant embryos have defects in neural crest morphogenesis. (A,A') crestin⁺ cells form segmentally arranged clusters prior to ganglion formation in wild-type embryos (e.g. arrow in A) but appear to migrate past their normal target sites in picasso mutant embryos (e.g. arrowhead in A'). (B,B') mitfa⁺ cells in wild-type exhibit some segmental patterning and a defect in picasso mutants similar to that of crestin⁺ cells. (C,C') dct⁺ melanoblast distributions do not differ consistently between wild-type and picasso mutant embryos. (D,D') Anti-Hu immunoreactivity shows dorsal root ganglia (e.g. arrow in D) and sympathetic ganglia (e.g. arrowhead in D) in wild-type larvae but their absence in picasso mutants. Scale bar: in A', 800 µm for A-C'; in D', 600 µm for D-D'.

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