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Fig. 12. Cryptic ErbB requirements during metamorphosis revealed by sensitized
genetic backgrounds. (A) kit mutants (reared with DMSO)
develop fewer metamorphic melanophores than wild type. (B) kit
mutants reared during metamorphosis with AG1478 have an additional metamorphic
melanophore deficiency. (C) csf1r mutants have similar numbers
of melanophores to wild type through the middle metamorphic stage shown
(Parichy et al., 2000b).
(D) csfr1r mutants reared in AG1478 during metamorphosis
exhibit a sharp reduction in melanophore numbers, as well as increased larval
mortality (not shown). (E) Melanophore densities (±1 s.e.) are
moderately or significantly reduced in sensitized backgrounds when treated
with AG1478 (AG) or PD158780 (PD) compared with DMSO-only controls (con).
Shared letters above bars indicate treatments that are not significantly
different from one another (P>0.05) within each genetic
background. Treatment sample sizes are shown at the base of each bar. Scale
bar: in A, 300 µm for A,B; in C, 300 µm for C,D.
