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Figure 3


Fig. 3. In erbb3b mutants, neural crest cells fail to pause in the location where DRGs normally form. Single frames taken from confocal time-lapse movies of 22-70 hpf Tg(sox10:GFP) zebrafish. In wild-type embryos (A,D,G,J,M), NC cells pause at the dorsal and ventral aspects of the notochord for more than 24 hours. By contrast, in erbb3b mutants (B,E,H,K,N) and in AG1478-treated wild type (C,F,I,L,O), NC cells did not pause and abnormally migrated away. Arrowheads indicate pausing NC cells; asterisks indicate places where pausing NC cells are missing. Broken lines indicate dorsal aspect of notochord. Scale bar: 20 µm.





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